In what was a one-sided affair on the scoreboard, the Lady Wolves claimed victory by 71 points to remain undefeated at the top of the table.
With the Breakers missing key players in Isabella Riley and Loni McBay, the Lady Breakers held up considerably well defensively when under fire, with Wodonga's Melanie Kirby (31 points), Casey Ardern (30) and Charlotte Beaven (20) all proficient shooters.
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Young Madison Gray led the Breakers offensively with her nine points, while Piper Poll lined up for her first game of the season.
Despite the margin, Benalla Basketball Association president Wally Armstrong said he was extremely proud of the way the Lady Breakers went about the challenge.
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“I'm proud of the girls to go up there this weekend, with key players out and play like they did against an extremely strong outfit,” Armstrong said.
“I don't think the scoreboard reflected the game.
“I believe our girls learnt a lot out of it - I was really impressed with them.”
Benalla Lady Breakers will now have a week break ahead of its rematch against Myrtleford Saints in round five.
Score: Benalla Lady Breakers 41 def by Wodonga Lady Wolves 112
Top scorers: Madison Gray 9, Chelsea Gilcrist 8, Kirsty Spinks 8